A survey of opsin localization, glycosylation, and light/chromophore influence on degeneration in 26 rhodopsin-associated retinitis pigmentosa models
Aaron D. Loewen, Beatrice M. Tam, Colette N. Chiu, Ross T Scharbach, Orson L. Moritz
This study examines RHO mutations in 26 RP models, finding that some cause light-dependent degeneration and others involve proteolytic cleavage and mislocalization.
bioRxiv · Jul 23, 2025 · PreprintCell Biology