Author

Aaron D. Loewen

University of British ColumbiaORCID 0000-0002-1392-6430Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:C. elegans· 1 Research Focus:cell type annotation· 1 Assay:proteomics· 1 Organism:Xenopus· 1

Frequent Co-Authors

Beatrice M. Tam· 1 shared Catharine H. RankiniD· 1 shared Colette N. Chiu· 1 shared Donald G. Moerman· 1 shared Joseph LiangiD· 1 shared Kota MizumotoiD· 1 shared Orson L. MoritziD· 1 shared Ross T Scharbach· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCell Biology

Beatrice M. Tam

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintJul 23, 2025

A survey of opsin localization, glycosylation, and light/chromophore influence on degeneration in 26 rhodopsin-associated retinitis pigmentosa models

Aaron D. Loewen, Beatrice M. Tam, Colette N. Chiu…·Orson L. Moritz

This study examines RHO mutations in 26 RP models, finding that some cause light-dependent degeneration and others involve proteolytic cleavage and mislocalization.

DOI 10.1101/2025.07.23.665973

Xenopusproteomics

𝕏 PostBluesky

Molecular BiologyDisease Models & MechanismsPeer-reviewedJan 1, 2018

CRISPR-Cas9 human gene replacement and phenomic characterization in Caenorhabditis elegans to understand the functional conservation of human genes and decipher variants of uncertain significance

Troy A. McDiarmid, Vinci Au, Aaron D. Loewen…·Catharine H. Rankin

This paper uses CRISPR-Cas9 in C. elegans to replace human genes and assess their function, showing it can classify disease variants accurately.

44 citations

C. elegansexperimental assay

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