Orson L. Moritz

Alterations in phototransduction timing, dark adaptation and GNAT1 trafficking in GNAT1-edited Xenopus laevis.

The paper examines the effects of GNAT1 mutations in Xenopus laevis, showing altered phototransduction timing, dark adaptation, and GNAT1 trafficking in different genetic backgrounds.

RPE65 knockout Xenopus laevis have a compromised but detectable electroretinogram and altered visual responses, without retinal degeneration or altered melanophore dispersion

A survey of opsin localization, glycosylation, and light/chromophore influence on degeneration in 26 rhodopsin-associated retinitis pigmentosa models

This study examines RHO mutations in 26 RP models, finding that some cause light-dependent degeneration and others involve proteolytic cleavage and mislocalization.

Prominin-1 null Xenopus laevis develop subretinal drusenoid-like deposits, cone-rod dystrophy, and dysmorphic retinal pigment epithelium.

This study shows that prom1-null Xenopus laevis develop subretinal drusenoid-like deposits and retinal degeneration, indicating RPE dysfunction precedes photoreceptor loss.

Synchronized photoactivation of T4K rhodopsin causes a chromophore-dependent retinal degeneration that is moderated by interaction with phototransduction cascade components.

This study investigates how T4K rhodopsin causes light-exacerbated retinal degeneration in Xenopus laevis, showing that photoactivation is toxic and that cell death is mitigated by interactions with phototransduction proteins.