G34R cancer mutation alters the conformational ensemble and dynamics of the histone H3.3 tails
Harrison A. Fuchs, Yunhui Peng, Shine Ayyapan, Ruben Rosas, Houfang Zhang, Anna R. Panchenko, Catherine A. Musselman
This study examines how the G34R and G33R mutations in histone H3.3 affect nucleosome structure and dynamics using NMR and molecular dynamics simulations.
Nucleic Acids Research · Nov 23, 2025Peer-reviewedBiophysics