Author

Shine Ayyapan

Herbert Irving Comprehensive Cancer Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Catherine A. MusselmaniD· 2 shared Harrison A. FuchsiD· 2 shared Aaron D. VinyiD· 1 shared Abby SundquistiD· 1 shared Angeliki GardikiotiiD· 1 shared Anna R. PanchenkoiD· 1 shared Edna M. StewartiD· 1 shared Grace ForsythiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiophysics

Catherine A. MusselmanORCID

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2 papers

Recent·Most cited

G34R cancer mutation alters the conformational ensemble and dynamics of the histone H3.3 tails

Harrison A. Fuchs, Yunhui Peng, Shine Ayyapan, Ruben Rosas, Houfang Zhang, Anna R. Panchenko, Catherine A. Musselman

This study examines how the G34R and G33R mutations in histone H3.3 affect nucleosome structure and dynamics using NMR and molecular dynamics simulations.

Nucleic Acids Research · Nov 23, 2025Peer-reviewedBiophysics

Polyamines regulate cell fate by altering the activity of histone-modifying enzymes

Maya Emmons‐Bell, Abby Sundquist, Megan R. Rabon, Grace Forsyth, Sylvie E. Oldeman, Shine Ayyapan, Angeliki Gardikioti, Roshni A. de Souza, Jonathan Coene, Maryam H. Kamel, Harrison A. Fuchs, Varun S. Sudunagunta, Edna M. Stewart, Steven H. L. Verhelst, Joanna Smeeton, , Juan M. Schvartzman

This study shows that polyamines regulate cell fate by altering chromatin structure through interactions with histone-modifying enzymes.

bioRxiv · Jul 2, 2024 · PreprintCell Biology