Catherine A. Musselman

Direct Readout of Multivalent Chromatin Reader-Nucleosome Interactions by Nucleosome Mass Spectrometry

This paper introduces Nuc-MS, a method to directly analyze chromatin reader-nucleosome interactions by disassembling complexes and identifying histone proteoforms involved in binding.

G34R cancer mutation alters the conformational ensemble and dynamics of the histone H3.3 tails

This study examines how the G34R and G33R mutations in histone H3.3 affect nucleosome structure and dynamics using NMR and molecular dynamics simulations.

Nucleosome context regulates chromatin reader preference

The paper investigates how nucleosome context influences chromatin reader binding preferences using biochemical and genomic approaches, revealing that multivalent engagement often has regulatory effects beyond simple additivity.

Polyamines regulate cell fate by altering the activity of histone-modifying enzymes

This study shows that polyamines regulate cell fate by altering chromatin structure through interactions with histone-modifying enzymes.

Nucleosome conformation dictates the histone code

The paper shows that histone reader domains interact with PTMs in a nucleosome-dependent manner, necessitating a refinement of the histone code concept to the nucleosome level.

REPROGRAMMING CBX8-PRC1 FUNCTION WITH A POSITIVE ALLOSTERIC MODULATOR

This paper identifies UNC7040 as a potent CBX8-specific positive allosteric modulator that disrupts PRC1 function and reduces cancer cell proliferation.

Evolutionarily ancient BAH-PHD protein mediates Polycomb silencing

The paper identifies EPR-1 as an H3K27 methylation effector in Neurospora crassa and shows its evolutionary conservation across eukaryotes.