Yunhui Peng

This study examines how the G34R and G33R mutations in histone H3.3 affect nucleosome structure and dynamics using NMR and molecular dynamics simulations.

The paper assesses the oncogenic potential of histone missense mutations using whole-exome sequencing data from over 12,000 cancer patients, finding that these mutations affect DNA repair interactions and increase mutagenesis.

The paper investigates how changes in histone protonation states affect nucleosome electrostatic potentials and interactions with partner proteins, and how cancer mutations influence these interactions.

The paper introduces NuPose, a deep residual network for predicting nucleosome positions and associated features across the genome with high accuracy.

The paper develops a computational method to predict cell-type-specific nucleosome-binding abilities of transcription factors using ChIP-seq, MNase-seq, and DNase-seq data, identifying new potential pioneer transcription factors.