Cytosolic Carboxypeptidase 5 maintains mammalian ependymal multicilia to ensure proper homeostasis and functions of the brain
Rubina Dad, Yujuan Wang, Chuyu Fang, Yuncan Chen, Yuan Zhang, Xinwen Pan, Xinyue Zhang, Emily Swanekamp, Krish Patel, Matthias T. F. Wolf, Zhiguang Yuchi, Xueliang Zhu, Hui‐Yuan Wu
This study identifies CCP5's N-domain as critical for ependymal multicilia stability, polarization, and coordination, preventing hydrocephalus in mice.
bioRxiv · Dec 30, 2024 · PreprintCell Biology