Phylogeny-agnostic strain-level prediction of phage-host interactions from genomes
Avery J. C. Noonan, Lucas Morinière, Edwin Omar Rivera-Lopez, Krish Patel, Melina Pena, Madeline Svab, Alexey E. Kazakov, Adam M. Deutschbauer, Edward G. Dudley, Vivek K. Mutalik, Adam P. Arkin
This paper develops a machine learning framework to predict strain-level phage-host interactions from genomes, achieving high accuracy without phylogenetic constraints.
bioRxiv · Nov 15, 2025 · PreprintMicrobiology