LRRK2-mediated phosphorylation of HDAC6 regulates HDAC6-cytoplasmic dynein interaction and aggresome formation.
Richard M. Lucas, Claudia S. Bauer, Kavitha Chinnaiya, Aurélie Schwartzentruber, Ruby MacDonald, Mark O. Collins, Jan Olav Aasly, Gunnar Brønstad, Laura Ferraiuolo, Heather Mortiboys, Kurt J. De Vos
This study identifies HDAC6 as a novel LRRK2 substrate and shows that LRRK2-mediated phosphorylation of HDAC6 enhances aggresome formation, linking LRRK2 dysfunction to Parkinson's disease pathology.
bioRxiv · Feb 19, 2019 · PreprintNeuroscience