Author

Claudia S. Bauer

University of Sheffield

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Organism:Drosophila· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Kurt J. De VosiD· 2 shared Laura FerraiuoloiD· 2 shared Adrian Higginbottom· 1 shared Alexander J. WhitworthiD· 1 shared Álvaro Sánchez-MartíneziD· 1 shared Amy Walton· 1 shared Aurélie Schwartzentruber· 1 shared Aytaç GüliD· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersMolecular Biology

Kurt J. De VosORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

A cell-penetrant peptide blocking C9ORF72-repeat RNA nuclear export suppresses neurodegeneration

Lydia M. Castelli, Ya-Hui Lin, Álvaro Sánchez-Martínez, Aytaç Gül, Kamallia Mohd Imran, Adrian Higginbottom, Santosh Kumar Upadhyay, Nóra M. Márkus, Raquel Rua Martins, Johnathan Cooper‐Knock, Claire Montmasson, Rebecca N. Cohen, Amy Walton, Claudia S. Bauer, Kurt J. De Vos, , Guillaume M. Hautbergue

This paper develops a cell-penetrant peptide that blocks C9ORF72-repeat RNA nuclear export, reducing neurodegeneration in preclinical models of ALS and FTD.

Science Translational Medicine · Mar 1, 2023Peer-reviewedMolecular Biology

LRRK2-mediated phosphorylation of HDAC6 regulates HDAC6-cytoplasmic dynein interaction and aggresome formation.

Richard M. Lucas, Claudia S. Bauer, Kavitha Chinnaiya, Aurélie Schwartzentruber, Ruby MacDonald, Mark O. Collins, Jan Olav Aasly, Gunnar Brønstad, Laura Ferraiuolo, Heather Mortiboys, Kurt J. De Vos

This study identifies HDAC6 as a novel LRRK2 substrate and shows that LRRK2-mediated phosphorylation of HDAC6 enhances aggresome formation, linking LRRK2 dysfunction to Parkinson's disease pathology.

bioRxiv · Feb 19, 2019 · PreprintNeuroscience