Kavitha Chinnaiya

Generation of human appetite-regulating neurons and tanycytes from stem cells

This study generates human appetite-regulating neurons and tanycytes from stem cells, identifying key progenitor markers and signaling mechanisms for hypothalamic subregion specification.

Resolving forebrain developmental organisation by analysis of differential growth patterns

The paper uses fate mapping and 4D modeling to reveal modular growth patterns in the chick forebrain, challenging the prosomere model and proposing a tripartite hypothalamus model.

Fgf signalling triggers an intrinsic mesodermal timer that determines the duration of limb patterning

The paper identifies Fgf signalling's role in triggering a mesodermal timer that controls limb patterning duration using an ex vivo chick wing explant system.

Single-cell analysis of early chick hypothalamic development reveals that hypothalamic cells are induced from prethalamic-like progenitors.

This study uses single-cell RNA-Seq to analyze early chick hypothalamic development, revealing that hypothalamic cells originate from prethalamic-like progenitors and identifying novel molecular regulators.

The neural cell adhesion molecule NrCAM regulates development of hypothalamic tanycytes

This study shows that NrCAM regulates adult hypothalamic tanycytes, affecting their numbers and marker expression, but with only subtle metabolic consequences.

Crumbs 2 mediates ventricular layer remodelling to form the adult spinal cord central canal

The paper shows that Crumbs2 (CRB2) mediates dorsal collapse in the spinal cord by promoting cell delamination and ventricular layer remodelling.

LRRK2-mediated phosphorylation of HDAC6 regulates HDAC6-cytoplasmic dynein interaction and aggresome formation.

This study identifies HDAC6 as a novel LRRK2 substrate and shows that LRRK2-mediated phosphorylation of HDAC6 enhances aggresome formation, linking LRRK2 dysfunction to Parkinson's disease pathology.