Parkinson's disease linked LRRK2 G2019S drives oxidative nuclear DNA damage and PARP1 hyperactive signaling
Jennifer Liu, Claudia P. González-Hunt, Tara Richbourg, Ivana Barraza, Carolyn G. Chen, Carlos Montes, Lingyan Ma, Ruihua Cao, Vishruth Hanumaihgari, Natalie R. Gassman, Elise Fouquerel, Laurie H. Sanders
This study shows that the LRRK2 G2019S mutation causes oxidative nuclear DNA damage and PARP1 hyperactivation, leading to cellular vulnerability in Parkinson's disease.
bioRxiv · Mar 1, 2026 · PreprintCell Biology