IRE1α and IRE1β Protect Intestinal Epithelium and Suppress Colorectal Tumorigenesis through Distinct Mechanisms
Ruishu Deng, Miao Wang, Thanyarat Promlek, Clementine Druelle-Cedano, Rabi Murad, Nicholas Davidson, Randal J. Kaufman
This study investigates the roles of IRE1α and IRE1β in intestinal epithelial cells, showing they protect against colorectal tumorigenesis through distinct mechanisms.
bioRxiv · May 1, 2025 · PreprintCancer Biology