SIRT2 Mediates Integrated Stress Response by Deacetylating and Stabilizing 4EBP1 to Suppress Translation
Yanlin Zi, Jiaqi Zhao, Miao Wang, Dan Hou, Richard A. Cerione, Hening Lin
This study identifies SIRT2 as a regulator of translation by deacetylating and stabilizing 4EBP1, which suppresses protein synthesis under amino acid limitation.
EMBO Reports · May 18, 2026Peer-reviewedCell Biology