Randal J. Kaufman

This study investigates the roles of IRE1α and IRE1β in intestinal epithelial cells, showing they protect against colorectal tumorigenesis through distinct mechanisms.

This study shows that the unfolded protein response declines with age in the heart, leading to protein misfolding and cardiac dysfunction.

This study identifies factors causing FVIII aggregation in the ER and shows that chaperones and glucose metabolism regulate its solubility and secretion.

This paper develops a mouse model with an epitope-tagged BiP/GRP78 protein to study its interactome and role in ER protein misfolding in vivo.