In vitro-prepared A30P alpha-synuclein fibrils adopt the conserved and disease-relevant Greek key fold
Moses H. Milchberg, Owen A. Warmuth, Collin G. Borcik, Ruixian Han, Benjamin D. Harding, Barry E. DeZonia, Dhruva D. Dhavale, Joshua A. Pierson, Paul T. Kotzbauer, Elizabeth Wright, Charles D. Schwieters, Chad M. Rienstra
The paper reports the high-resolution SSNMR structure of A30P mutant alpha-synuclein fibrils, showing a conserved Greek key fold not including the mutation site, and validates a method for comparing SSNMR spectra of Asyn polymorphs.
The Journal of Physical Chemistry B · Jul 2, 2026Peer-reviewedBiophysics