Helminth-remodeled microbial indole-3-lactic acid drives AhR-dependent disease tolerance
Ruohang Sun, Yi Liu, Yue Wang, Nuo Xu, Xiaoxiao Ma, Qingbo Lv, Xiufeng Zhao, Isabelle Vallée, Pascal Boireau, Zeming Wu, M Y Liu, Xiaolei Liu, Xuemin Jin
This study shows helminth infection remodels gut microbiota to produce ILA, which activates AhR to promote immune tolerance and reduce inflammation in viral infections.
bioRxiv · May 8, 2026 · PreprintImmunology