Remodeling of purinergic signaling in the paraventricular hypothalamus promotes hyperphagic obesity and insulin resistance
Yu Liu, Anastasiia Bondarenko, Haiyang Zhang, Pengwei Luan, Qian Zhang, Bo Wang, Syeda Sadia Najam, Xian Liang, Ali Alamdar Shah Syed, Dongfa Lin, Shangyuan Huang, Ruslan Konovalov, Witold Konopka, Zhi Long Zhang, Yi Zhang, , Ilya A. Vinnikov
This study shows that high-fat diet induces purinergic signaling in the hypothalamus, leading to obesity and insulin resistance, and that targeting P2Y12 can reverse these effects.
bioRxiv · Jul 2, 2024 · PreprintNeuroscience