Author

Xian Liang

Fudan UniversityORCID 0000-0002-0175-3499Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:metabolism & bioenergetics· 1 Organism:mouse· 1 Organism:non-human primate· 1 Organism:rat· 1

Frequent Co-Authors

Alberto M. PereiraiD· 1 shared Ali Alamdar Shah SyediD· 1 shared Anastasiia Bondarenko· 1 shared Andries KalsbeekiD· 1 shared Anhui Wang· 1 shared Bo Wang· 1 shared Chun‐Xia YiiD· 1 shared Dirk Jan StenversiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperImmunology

Alberto M. PereiraORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Limited microglial metabolic improvement with time-restricted feeding in diet-induced obesity

Han Jiao, Jarne Jermei, Xian Liang, Hendrik J.P. van der Zande, Frank Vrieling, Valentina Sophia Rumanova, Milan Dorscheidt, Felipe Corrêa‐da‐Silva, Anhui Wang, Ewout Foppen, Alberto M. Pereira, Dirk Jan Stenvers, TieMin LIU, Kimberly Bonger, Rinke Stienstra, , Chun‐Xia Yi

This study examines how time-restricted feeding affects microglial immunometabolism in obese rats, finding that TRF during the active phase reduces fat mass and alters microglial transcriptome rhythmicity, but does not reverse HFD-induced metabolic inflexibility.

Cell Reports · Oct 1, 2025Peer-reviewedImmunology

Remodeling of purinergic signaling in the paraventricular hypothalamus promotes hyperphagic obesity and insulin resistance

Yu Liu, Anastasiia Bondarenko, Haiyang Zhang, Pengwei Luan, Qian Zhang, Bo Wang, Syeda Sadia Najam, Xian Liang, Ali Alamdar Shah Syed, Dongfa Lin, Shangyuan Huang, Ruslan Konovalov, Witold Konopka, Zhi Long Zhang, Yi Zhang, , Ilya A. Vinnikov

This study shows that high-fat diet induces purinergic signaling in the hypothalamus, leading to obesity and insulin resistance, and that targeting P2Y12 can reverse these effects.

bioRxiv · Jul 2, 2024 · PreprintNeuroscience