Pentose Phosphate Pathway Protects E. coli from Antibiotic Lethality
Tatyana A. Seregina, Rustem S. Shakulov, Konstantin Y. Shatalin, Svetlana A. Sklyarova, Irina Yu. Petrushanko, Vladimir A. Mitkevich, Alexander А. Makarov, Alexander S. Mironov, Evgeny Nudler
This paper shows that disrupting the pentose phosphate pathway in E. coli activates an anabolic variant that increases antibiotic susceptibility, while ribose-5-phosphate metabolism enhances bacterial tolerance.
bioRxiv · Sep 7, 2024 · PreprintMicrobiology