Evgeny Nudler

This study shows H-NS silences bacterial antiviral immunity by compacting chromatin, and its deletion enhances phage defense in E. coli.

This paper characterizes OLD, an abortive immunity protein, revealing its structure and activation mechanism in response to phage replication and DNA defects in RecBCD-compromised cells.

This study identifies ZCWPW1 as a chromatin-based regulator of telomere architecture and meiotic chromosome movements, independent of PRDM9.

This study shows that cysteine restriction in mice causes rapid weight loss by depleting glutathione and coenzyme A, activating stress responses, and increasing lipolysis.

This paper shows that disrupting the pentose phosphate pathway in E. coli activates an anabolic variant that increases antibiotic susceptibility, while ribose-5-phosphate metabolism enhances bacterial tolerance.

This study identifies persistent RNA polymerase II backtracking in human cells and shows its enrichment in genes involved in translation, replication, and development.

The paper identifies CedA as a general transcription factor in E. coli that stabilizes an open-promoter complex without contacting DNA and modulates gene expression under stress conditions.

The paper shows that NPM1 is essential for the inheritance of repressed chromatin domains during DNA replication in mouse embryonic stem cells.

The paper investigates how phosphorylated nucleotides like remdesivir triphosphate and ppGpp activate SARS-CoV-2 RdRp through allosteric mechanisms involving the NiRAN domain and Nsp7/8 subunits.

The paper identifies YcjW as a transcription factor that enables alternative H2S production in E. coli lacking 3MST, enhancing antibiotic and oxidative stress tolerance.

The paper investigates how cross-linker length and molecular motions affect XL-MS depth and distance restraints for protein-protein docking.

The paper describes an automated workflow for discovering and simulating protein-protein complexes using in vivo chemical cross-linking and mass spectrometry.