Author

Ruth A. Howe

Johns Hopkins University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:host-pathogen & immune response· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:protein folding & dynamics· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Binayak RimaliD· 4 shared Gyanu LamichhaneiD· 4 shared Chandra M. Panthi· 3 shared Guoqing ChengiD· 2 shared Chavis Tabor· 1 shared Evan Chen· 1 shared Jay KhandelwaliD· 1 shared Ngan Anh Nguyen· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

9 top collaborators · 27 mutual co-author links

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4 shared papersMicrobiology

Binayak RimalORCID

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Author profile →

4 papers

Recent·Most cited

Expanding the scope of Mycobacterium abscessus reference strains to improve pulmonary disease modeling

Ruth A. Howe, Chavis Tabor, Chandra M. Panthi, Guoqing Cheng, Binayak Rimal, Evan Chen, Ngan Thi Kim Nguyen, Gyanu Lamichhane

This study identifies Mab clinical isolates that better model human pulmonary disease compared to the commonly used ATCC 19977 strain in mouse models.

Disease Models & Mechanisms · Aug 1, 2026Peer-reviewedMicrobiology

Efficacies of sequenced monotherapies of Mycobacterium avium lung infection in mouse

Ruth A. Howe, Binayak Rimal, Jay Khandelwal, Chandra M. Panthi, Gyanu Lamichhane

This study evaluates sequential monotherapy for M. avium lung infection in mice, finding it as effective as multidrug therapy without promoting resistance.

The Journal of Infectious Diseases · Dec 18, 2025Peer-reviewedMicrobiology

Predicting Mycobacterium abscessus proteins with atypical amino acid composition essential for human infections

Guoqing Cheng, Ruth A. Howe, Binayak Rimal, Ngan Anh Nguyen, Gyanu Lamichhane

The paper identifies 10 unique proteins in Mycobacterium abscessus with restricted evolutionary variation and atypical amino acid composition, suggesting their essential role in human infections.

bioRxiv · Mar 24, 2025 · PreprintMicrobiology

Regimen comprising clarithromycin, clofazimine and bedaquiline is more efficacious than monotherapy in a mouse model of chronic Mycobacterium avium lung infection

Binayak Rimal, Ruth A. Howe, Chandra M. Panthi, Gyanu Lamichhane

The paper evaluates antibiotic regimens in a mouse model of M. avium infection, finding that a triple-drug regimen is more effective than monotherapy.

Antimicrobial Agents and Chemotherapy · Mar 14, 2025Peer-reviewedMicrobiology