Gyanu Lamichhane

This study identifies extensive proteomic changes in Mycobacterium abscessus under carbon starvation, highlighting the role of the DosRS system in non-replicating persistence.

This study identifies Mab clinical isolates that better model human pulmonary disease compared to the commonly used ATCC 19977 strain in mouse models.

This study identifies β-lactam targets in Mycobacterium abscessus using chemoproteomics, revealing 17 conserved targets and demonstrating imipenem's superior inhibition over cefoxitin.

This study evaluates sequential monotherapy for M. avium lung infection in mice, finding it as effective as multidrug therapy without promoting resistance.

This study identifies 30 Mtb enzymes inhibited by meropenem, revealing polypharmacology beyond known cell wall targets.

This study shows that combinations of dual β-lactams and β-lactamase inhibitors synergistically inhibit Mycobacterium abscessus growth, challenging the traditional view of their mechanisms.

This study characterizes the proteomic changes in Mycobacterium tuberculosis under carbon starvation, revealing extensive reprogramming and retention of cell wall biosynthesis enzymes.

The paper identifies 10 unique proteins in Mycobacterium abscessus with restricted evolutionary variation and atypical amino acid composition, suggesting their essential role in human infections.

The paper evaluates antibiotic regimens in a mouse model of M. avium infection, finding that a triple-drug regimen is more effective than monotherapy.

This study establishes a murine model of progressive Mycobacterium abscessus lung infection under corticosteroid treatment, demonstrating its progression to pathology.