Identification of potent biparatopic antibodies targeting FGFR2 fusion driven cholangiocarcinoma.
Saireudee Chaturantabut, Sydney Oliver, Dennie Tompers Frederick, Jiwan Kim, Foxy P. Robinson, Alessandro Sinopoli, Tianyu Song, Yao He, Y.H. Chang, Diego J. Rodriguez, Liang Chang, Devishi Kesar, Meilani Ching, Ruvimbo Dzvurumi, Adel Atari, , William R. Sellers
The paper identifies biparatopic antibodies targeting FGFR2 extracellular domain that effectively block FGFR2 fusion-driven cholangiocarcinoma signaling and growth.
Journal of Clinical Investigation · Feb 27, 2025Peer-reviewedCancer Biology