Leveraging unbiased LC-MS analysis to identify histone post-translational modifications associated with age-related decline of learning and memory
S. Bhatt, Hasini A. Kalpage, Smaranda Bodea, Leticia Pérez‐Sisqués, Ryan Gerkman, An Chi, M. Albert Basson, Sébastien Gillotin
This paper uses mass spectrometry to identify age- and activity-dependent changes in histone post-translational modifications in mouse hippocampi, proposing a framework for integrating these findings into ageing research.
bioRxiv · Dec 9, 2025 · PreprintNeuroscience