Leticia Pérez‐Sisqués

Inhibition of histone lysine demethylase restores learning and memory in aged mice

This study shows that inhibiting LSD1, a histone demethylase, restores learning and memory in aged mice by reversing age-related defects in H3K4me3 dynamics and synaptic plasticity.

Leveraging unbiased LC-MS analysis to identify histone post-translational modifications associated with age-related decline of learning and memory

This paper uses mass spectrometry to identify age- and activity-dependent changes in histone post-translational modifications in mouse hippocampi, proposing a framework for integrating these findings into ageing research.

Deficiency of the histone lysine demethylase KDM5B causes autism-like phenotypes via increased NMDAR signalling

This study shows that KDM5B deficiency in mice leads to autism-like behaviors and increased brain size, which can be mitigated by NMDAR antagonists.

RTP801 REGULATES MOTOR CORTEX SYNAPTIC TRANSMISSION AND LEARNING

This study shows that RTP801 regulates synaptic transmission and motor learning by modulating synaptic plasticity in the motor cortex.

SYNAPTIC RTP801 CONTRIBUTES TO MOTOR LEARNING DYSFUNCTION IN HUNTINGTON DISEASE

This study shows that RTP801 mediates motor learning dysfunction in Huntington's disease by affecting synaptic plasticity, suggesting a therapeutic target through the RTP801/Akt/mTOR pathway.