Does blood pressure level matter more in individuals with higher genetic risk of dementia? A polygenic interaction study in the UK Biobank
Phazha LK Bothongo, Ryan Mattick, Victoria Taylor‐Bateman, Patrick G. Kehoe, Yoav Ben‐Shlomo, Emma Louise Anderson
This study investigates whether blood pressure interacts with genetic risk of dementia to influence dementia diagnosis, finding that higher systolic blood pressure increases dementia risk regardless of genetic predisposition.
medRxiv · Jul 14, 2025 · PreprintGenetic & Genomic Medicine