Patrick G. Kehoe

This study investigates the Na+/K+ ratio in Alzheimer's disease and finds it is elevated in thalamus and CSF, correlating with Braak tangle stage.

This study investigates whether blood pressure interacts with genetic risk of dementia to influence dementia diagnosis, finding that higher systolic blood pressure increases dementia risk regardless of genetic predisposition.

This study identifies causes and consequences of vascular dementia using polygenic risk scores, phenome-wide association, and Mendelian randomization analyses from UK Biobank data, highlighting cardiometabolic and educational factors as key modifiable risks.

This paper uses Mendelian randomization to assess if existing drugs targeting lipid-lowering, anti-hypertensive, or anti-inflammatory pathways affect vascular dementia risk, finding potential benefits for beta-1 adrenergic receptor antagonists and risks for ACE inhibitors.

The paper analyzes exome data from 22,319 individuals to identify rare CNVs and 22q11.21 dosage as risk factors for Alzheimer's disease.

This study performs a meta-analysis of GWAS to identify new genetic loci associated with all-cause and vascular dementia, revealing shared and distinct risk factors.

This study uses Mendelian randomization to assess if antihypertensive drugs reduce Alzheimer’s disease risk by lowering systolic blood pressure, finding limited evidence of an effect.