Emma Louise Anderson

Evaluating Diabetes Drug Targets for Vascular Dementia Prevention Using Drug Target Mendelian Randomisation

This study uses Mendelian randomisation to assess if diabetes drug targets affect vascular dementia risk, finding no strong evidence but a suggestive protective effect for DPP4 inhibition.

Assessing the repurposing potential of disease-modifying antirheumatic drug targets to reduce Alzheimer's disease risk: a pQTL-based Mendelian randomization and colocalization analysis

This study uses pQTL-based Mendelian randomization and colocalization to assess if DMARD targets reduce Alzheimer's disease risk, finding only FCGR3B shows increased risk with higher plasma levels.

Does blood pressure level matter more in individuals with higher genetic risk of dementia? A polygenic interaction study in the UK Biobank

This study investigates whether blood pressure interacts with genetic risk of dementia to influence dementia diagnosis, finding that higher systolic blood pressure increases dementia risk regardless of genetic predisposition.

Causes and consequences of vascular dementia across the life course: Evidence from a UK Biobank phenome-wide and Mendelian randomization study

This study identifies causes and consequences of vascular dementia using polygenic risk scores, phenome-wide association, and Mendelian randomization analyses from UK Biobank data, highlighting cardiometabolic and educational factors as key modifiable risks.

Deciphering the Influence of Socioeconomic Status on Brain Structure: Insights from Mendelian Randomization

This study uses Mendelian randomization to investigate the causal relationship between socioeconomic status and brain structure, finding that SES is protective against white matter hyperintensities independent of cognitive ability.

Repurposing drugs for the prevention of vascular dementia: Evidence from drug target Mendelian randomization

This paper uses Mendelian randomization to assess if existing drugs targeting lipid-lowering, anti-hypertensive, or anti-inflammatory pathways affect vascular dementia risk, finding potential benefits for beta-1 adrenergic receptor antagonists and risks for ACE inhibitors.

Exploring the causal effects of genetic liability to ADHD and Autism on Alzheimer's disease

This study investigates causal links between genetic liability to ADHD, ASD, and Alzheimer's disease using Mendelian randomization, finding limited evidence of association.

The causes and consequences of Alzheimer's disease: phenome-wide evidence from Mendelian randomization

This study uses Mendelian randomization to identify causal risk factors for Alzheimer's disease, finding that education, fluid intelligence, and physical activity are likely causal, while most associations are consequences of early disease.

Causal effects of circulating cytokine concentrations on risk of Alzheimers disease: A bidirectional two-sample Mendelian randomization study

This study uses Mendelian randomization to investigate causal relationships between cytokine concentrations and Alzheimer's disease risk, finding weak evidence of a causal effect for some cytokines.

Effects of genetic liability to Alzheimers disease on circulating metabolites across the life course

This study examines how genetic risk for Alzheimer's disease affects plasma metabolites across different ages, finding strong associations with lipid traits, particularly influenced by the APOE4 isoform.

The bidirectional causal effects of brain morphology across the life course and risk of Alzheimers disease: A cross-cohort comparison and Mendelian randomization meta-analysis

This study uses Mendelian randomization to examine bidirectional causal effects between brain morphology and Alzheimer's disease risk across different life stages.

Is genetic liability to ADHD and ASD causally linked to educational attainment?

This paper uses Mendelian randomization to investigate causal links between genetic liability to ADHD/ASD and educational attainment, finding distinct causal effects for ADHD and ASD.

Genomic analysis of diet composition finds novel loci and associations with health and lifestyle

This study identifies genetic loci associated with macronutrient intake and links them to health outcomes using GWAS in over 235,000 individuals.

Education, intelligence and Alzheimer’s disease: Evidence from a multivariable two-sample Mendelian randomization study

This study uses Mendelian randomization to show education and intelligence both causally lower Alzheimer's disease risk, with intelligence having an independent effect.