Phazha LK Bothongo

Does blood pressure level matter more in individuals with higher genetic risk of dementia? A polygenic interaction study in the UK Biobank

This study investigates whether blood pressure interacts with genetic risk of dementia to influence dementia diagnosis, finding that higher systolic blood pressure increases dementia risk regardless of genetic predisposition.

Causes and consequences of vascular dementia across the life course: Evidence from a UK Biobank phenome-wide and Mendelian randomization study

This study identifies causes and consequences of vascular dementia using polygenic risk scores, phenome-wide association, and Mendelian randomization analyses from UK Biobank data, highlighting cardiometabolic and educational factors as key modifiable risks.

Repurposing drugs for the prevention of vascular dementia: Evidence from drug target Mendelian randomization

This paper uses Mendelian randomization to assess if existing drugs targeting lipid-lowering, anti-hypertensive, or anti-inflammatory pathways affect vascular dementia risk, finding potential benefits for beta-1 adrenergic receptor antagonists and risks for ACE inhibitors.