Author

Melanie R. Shapiro

University of FloridaORCID 0000-0003-2090-0877Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 3 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Assay:CITE-seq· 2 Approach:deep learning· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:flow cytometry· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Todd M. BruskoiD· 4 shared Amanda L. PosgaiiD· 3 shared Leeana D. PetersiD· 3 shared Andrew J. Fiore-GartlandiD· 2 shared Koshlan Mayer-BlackwelliD· 2 shared Mark A. AtkinsoniD· 2 shared Puneet RawatiD· 2 shared Victor GreiffiD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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4 shared papersImmunology

Todd M. BruskoORCID

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4 papers

Recent·Most cited

Genetic & Genomic MedicineScience AdvancesPeer-reviewedFeb 13, 2026

Identification of a type 1 diabetes-associated T cell receptor repertoire signature from the human peripheral blood

Puneet Rawat, Melanie R. Shapiro, Leeana D. Peters…·Todd M. Brusko

The paper identifies TCR subsequence motifs associated with type 1 diabetes using deep learning and shows their enrichment in T1D individuals based on HLA risk alleles.

10 citationstop 1%

humanCITE-seq

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ImmunologyPLoS Computational BiologyPeer-reviewedJan 16, 2026

TCR2HLA: calibrated inference of HLA genotypes from TCR repertoires enables identification of immunologically relevant metaclonotypes

Koshlan Mayer-Blackwell, Anastasia A. Minervina, Mikhail V. Pogorelyy…·Andrew J. Fiore-Gartland

TCR2HLA infers HLA genotypes from TCR repertoires, enabling identification of immunologically relevant metaclonotypes and discovery of HLA-associated TCRs.

3 citationstop 5%

humanscRNA-seq

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ImmunologyNature CommunicationsPeer-reviewedMay 18, 2025

Immune perturbations in human pancreas lymphatic tissues prior to and after type 1 diabetes onset

Gregory J. Golden, Vincent H. Wu, Jacob T. Hamilton…·Michael R. Betts

The paper analyzes immune cell changes in human pancreas-draining lymphatic tissues before and after T1D onset, identifying proinflammatory patterns and genetic risk correlations.

27 citationstop 1%

humanflow cytometry

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ImmunologyDiabetologiaPeer-reviewedDec 5, 2024

Inhibition of CD226 Co-Stimulation Suppresses Diabetes Development in the NOD Mouse by Augmenting Tregs and Diminishing Effector T Cell Function

Matthew E. Brown, Puchong Thirawatananond, Leeana D. Peters…·Todd M. Brusko

This study shows that blocking CD226 reduces diabetes in NOD mice by enhancing Treg function and reducing effector T cell activity.

13 citations

mouseproteomics

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