Amanda L. Posgai

The paper maps the morphological and functional maturation of human endocrine pancreas from birth to age 10 using pediatric tissue samples and imaging techniques.

This study uses spatial transcriptomics to identify inflammation signatures in pancreas and lymph node tissues of T1D patients, highlighting LTB and other genes involved in disease pathogenesis.

The paper identifies TCR subsequence motifs associated with type 1 diabetes using deep learning and shows their enrichment in T1D individuals based on HLA risk alleles.

This study integrates histopathological data from the human pancreas across T1D stages to identify novel histopathological correlates, particularly in the prodromal stage.

TCR2HLA infers HLA genotypes from TCR repertoires, enabling identification of immunologically relevant metaclonotypes and discovery of HLA-associated TCRs.

The paper uses 3D imaging to analyze pancreatic islets in healthy and type 1 diabetes (T1D) individuals, finding that islet size and composition influence their loss in T1D.

This study identifies aberrant immune regulation and stem-like CD8+ T cells in pancreatic lymph nodes during type 1 diabetes development using mass cytometry and single-cell RNA sequencing.

The paper uses imaging mass cytometry to analyze human pancreatic samples and identifies early β-cell dysfunction and immune changes in type 1 diabetes progression.

This study shows that blocking CD226 reduces diabetes in NOD mice by enhancing Treg function and reducing effector T cell activity.

The paper examines islet and acinar cell secretion in different pancreatic regions across diabetes stages, finding reduced insulin secretion and beta-cell volume in T1D with normal enzyme secretion.