Author

Koshlan Mayer-Blackwell

Fred Hutch Cancer CenterORCID 0000-0002-1652-4023Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Immunology· 3 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 4 Approach:deep learning· 3 Research Focus:cell type annotation· 2 Assay:CITE-seq· 2 Approach:statistical model· 2 Research Focus:clustering· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Andrew J. Fiore-GartlandiD· 4 shared Amanda L. PosgaiiD· 2 shared Anastasia A. MinervinaiD· 2 shared Leeana D. PetersiD· 2 shared Melanie R. ShapiroiD· 2 shared Paul Glyndwr ThomasiD· 2 shared Philip H BradleyiD· 2 shared Puneet RawatiD· 2 shared

Activity by Year

2026-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersImmunology

Andrew J. Fiore-GartlandORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

HIV-1 prime-boost vaccination shapes distinct clonal trajectories and memory precursor states of Env- and Gag-specific T cells

Guoyue Xu, Joshua X. Yee, Saskia Ilcisin, N Kaul, Koshlan Mayer-Blackwell, Ernest Moelhman, David Richard Glass, Anastasia A. Minervina, Shelly Karuna, Magdalena E. Sobieszczyk, Matthew R. Hart, Paul Glyndwr Thomas, Peter J. Skene, Stephen C. De Rosa, M. Juliana McElrath, , Evan William Newell

This study shows that HIV-1 DNA/rAd5 vaccination leads to distinct clonal expansion and memory precursor states in Env- and Gag-specific CD8 T cells.

bioRxiv · Sep 29, 2026 · PreprintImmunology

Deciphering antigen-driven T cell responses through vectorized TCRdist sequence neighborhood quantification

Sebastiaan Valkiers, Koshlan Mayer-Blackwell, Albert C. Yeh, Vincent M.L. Van Deuren, Andrew J. Fiore-Gartland, Geoffrey R. Hill, Kris Laukens, Pieter Meysman, Philip H Bradley

The paper introduces a computational framework to efficiently identify significantly neighbor enriched TCR sequences, demonstrating its utility in analyzing memory T cells and T cell responses to vaccination and viral infections.

bioRxiv · Apr 14, 2026 · PreprintImmunology

Identification of a type 1 diabetes-associated T cell receptor repertoire signature from the human peripheral blood

Puneet Rawat, Melanie R. Shapiro, Leeana D. Peters, Michael Widrich, Koshlan Mayer-Blackwell, Keshav Motwani, Milena Pavlović, Ghadi al Hajj, Amanda L. Posgai, Chakravarthi Kanduri, Giulio Isacchini, Maria Chernigovskaya, Lonneke Scheffer, Kartik Motwani, Leandro Octavio Balzano-Nogueira, , Todd M. Brusko

The paper identifies TCR subsequence motifs associated with type 1 diabetes using deep learning and shows their enrichment in T1D individuals based on HLA risk alleles.

Science Advances · Feb 13, 2026Peer-reviewedGenetic & Genomic Medicine

TCR2HLA: calibrated inference of HLA genotypes from TCR repertoires enables identification of immunologically relevant metaclonotypes

Koshlan Mayer-Blackwell, Anastasia A. Minervina, Mikhail V. Pogorelyy, Puneet Rawat, Melanie R. Shapiro, Leeana D. Peters, Emily S. Ford, Amanda L. Posgai, Kasi Vegesana, Samuel S. Minot, David M. Koelle, Victor Greiff, Philip H Bradley, Todd M. Brusko, Paul G. Thomas, Andrew J. Fiore-Gartland

TCR2HLA infers HLA genotypes from TCR repertoires, enabling identification of immunologically relevant metaclonotypes and discovery of HLA-associated TCRs.

PLoS Computational Biology · Jan 16, 2026Peer-reviewedImmunology