Cell BiologyMolecular MetabolismPeer-reviewed
Permanent Neonatal diabetes-causing Insulin mutations have dominant negative effects on beta cell identity
Yuwei Zhang, Lina Sui, Qian Du…·Dieter M. Egli
This study investigates two INS mutations causing permanent neonatal diabetes, showing they impair beta cell function through misfolded proinsulin, ER stress, and dedifferentiation.
16 citations