Peter R. Arvan

SEL1L-HRD1 ER-Associated Degradation Facilitates Prohormone Convertase 2 Maturation and Glucagon Production in Islet α Cells

This study identifies SEL1L-HRD1 ERAD as a regulator of PC2 maturation and glucagon production in islet α cells by degrading misfolded proPC2.

Small molecule FICD inhibitors suppress endogenous and pathologic FICD-mediated protein AMPylation

This study identifies two small molecule inhibitors of FICD that suppress both endogenous and pathologic protein AMPylation, improving proinsulin processing in β cells.

Adaptation to chronic ER stress enforces pancreatic β-cell plasticity

This study shows chronic ER stress induces β-cell plasticity, but excessive stress leads to identity loss and is linked to T1D progression.

Epitope-tagging of the endogenous murine BiP/GRP78/Hspa5 locus allows direct analysis of the BiP interactome and protein misfolding in vivo

This paper develops a mouse model with an epitope-tagged BiP/GRP78 protein to study its interactome and role in ER protein misfolding in vivo.

Requirement for TRanslocon-Associated Protein (TRAP) α in insulin biogenesis

This study identifies TRAP as essential for insulin biogenesis, showing it facilitates preproinsulin translocation and affects downstream processing and secretion.