Uncoupling from transcription protects polyadenylation site cleavage from inhibition by DNA damage
Rym Sfaxi, Biswendu Biswas, Galina Boldina, Mandy Cadix, Nicolas Servant, Huimin Chen, Daniel R. Larson, Martin Dutertre, Caroline Robert, Stéphan Vagner
The paper shows that post-transcriptional PAS cleavage of p53 pre-mRNA allows it to escape DNA damage inhibition, and identifies other DDR-related pre-mRNAs with similar mechanisms.
The EMBO Journal · Feb 10, 2023Peer-reviewedMolecular Biology