Galina Boldina

The paper shows that intronic polyadenylation (IPA) of MET affects tumour progression and therapy resistance by producing a short MET isoform that reduces invasiveness and enhances response to MAPK-targeted therapy.

The paper shows that post-transcriptional PAS cleavage of p53 pre-mRNA allows it to escape DNA damage inhibition, and identifies other DDR-related pre-mRNAs with similar mechanisms.

The paper introduces ASigNTF, a method to estimate cell-type abundance from transcriptomic data using non-negative tensor factorization and the Herfindahl-Hirschman index, and provides two new immune cell-type signatures that outperform existing methods.