Stéphan Vagner

This study shows RNA directly interacts with BRAF to regulate MAPK signaling by facilitating RAF complex formation and MEK1/2 phosphorylation.

This study shows that blocking U1 snRNA increases cisplatin-induced DNA damage and sensitizes lung cancer cells to genotoxic agents by affecting DNA repair gene expression.

This study shows that translational control of 53BP1 mRNA regulates adaptive mutability in melanoma cells, and targeting eIF4A reduces resistance to BRAF/MEK inhibitors.

This study identifies a non-metabolic role for hexokinase 2 as an RNA-binding protein that regulates SOX10 mRNA translation in melanoma, independent of its glycolytic activity.

The paper identifies microproteins encoded by intronic polyadenylation isoforms in the 5' part of genes and shows their role in modulating cisplatin response in cancer cells.

This study shows 53BP1 interacts with RNA primers from Okazaki fragments during DNA replication, supporting their processing and highlighting an RNA-protein interaction at replication forks.

The paper shows that intronic polyadenylation (IPA) of MET affects tumour progression and therapy resistance by producing a short MET isoform that reduces invasiveness and enhances response to MAPK-targeted therapy.

The paper shows that post-transcriptional PAS cleavage of p53 pre-mRNA allows it to escape DNA damage inhibition, and identifies other DDR-related pre-mRNAs with similar mechanisms.