Epigenetic-metabolic axis in the temporal scaling of mammalian cortical neurogenesis across species
Quan Wu, Charlotte Manser, Taeko Suetsugu, Ryo Yoshida, Hideya Sakaguchi, Yo-ichi Nabeshima, Hiroshi Kiyonari, Rubén Perez‐Carrasco, Fumio Matsuzaki
The paper identifies H3K27me3-mediated repression and -ketoglutarate as key regulators of species-specific neurogenesis timescales across mammals.
bioRxiv · Sep 23, 2025 · PreprintDevelopmental Biology