Hiroshi Kiyonari

Ductal myofibroblasts reactivate contractile program to stabilize alveolar architecture during lung regeneration

The paper identifies ductal myofibroblasts as critical for maintaining alveolar structure during lung regeneration through reactivation of a contractile program.

A single-nucleus and spatial transcriptomic atlas of the Syrian hamster preoptic area across hibernation states

This study creates a transcriptomic atlas of the Syrian hamster preoptic area using snRNA-seq and spatial transcriptomics, comparing seasonal and hibernation states.

Mutation-agnostic gene insertion therapy for RHO-associated autosomal dominant retinitis pigmentosa using zinc finger nucleases

This paper develops a mutation-agnostic gene insertion therapy for RHO-adRP using ZF-ND1-mediated HITI and validates its efficacy and safety in preclinical models.

Genome editing of marsupial RSX reveals conserved and divergent principles in mammalian X-inactivation

This study uses CRISPR-Cas9 in opossums to show RSX is required for initiating X-inactivation, with divergent Polycomb regulation compared to eutherians.

Divergent mechanics of inner ear morphogenesis are coupled to developmental tempo over vertebrate evolution

The paper examines inner ear morphogenesis across 12 vertebrate species, finding that divergent mechanical processes in tissue expansion are coordinated with developmental tempo to maintain conserved morphology.

Conserved interhemispheric morphogenesis in amniotes preceded the evolution of the corpus callosum

The paper shows that interhemispheric remodeling, a precursor to corpus callosum formation, is conserved in non-mammalian amniotes and plays a role in forming similar structures in reptiles and birds.

Epigenetic-metabolic axis in the temporal scaling of mammalian cortical neurogenesis across species

The paper identifies H3K27me3-mediated repression and -ketoglutarate as key regulators of species-specific neurogenesis timescales across mammals.

Kif11-haploinsufficient oocytes reveal spatially differential requirements for chromosome biorientation in the spindle

This study shows that Kif11 haploinsufficiency in mouse oocytes leads to impaired spindle bipolarization and spatially differential chromosome biorientation.

Role Of Pcdh15 In The Development Of Intrinsic Polarity Of Inner Ear Hair Cells

The paper investigates the role of Pcdh15-CD2 in establishing intrinsic polarity of inner ear hair cells, showing its necessity for kinocilial migration and polarity restoration.

Post-fertilization transcription initiation in an ancestral LTR retrotransposon drives lineage-specific genomic imprinting of ZDBF2

The paper shows that an ancestral LTR retrotransposon insertion in the common ancestor of Euarchontoglires drives lineage-specific genomic imprinting of ZDBF2 through post-fertilization transcription initiation.

Dietary Availability Acutely Governs Puberty Onset via Hypothalamic Neural Circuit

This study shows that dietary availability affects puberty onset in female mice by modulating the activity of arcuate kisspeptin neurons through a neural circuit involving Agrp neurons.

Post-synaptic competition between calcineurin and PKA regulates mammalian sleep-wake cycles

The paper identifies PKA and phosphatases as regulators of sleep-wake cycles through genetic and functional studies in mice.

Targeting of retrovirus-derived Rtl8a/8b reduces social response and increases apathy-like behavior associated with GABRB2 reduction

This study shows that knocking out Rtl8a and Rtl8b in mice leads to reduced social behavior, increased apathy, and obesity, likely due to decreased GABRB2 expression in the brain.

PD-1 negatively regulates helper T cell differentiation into Th2

This study shows PD-1 inhibits Th2 cell differentiation and allergic inflammation in mice, suggesting its therapeutic potential for Th2-driven diseases.

Postnatal xanthine metabolism regulates cardiac regeneration in mammals

This study shows that postnatal xanthine metabolism regulates cardiac regeneration by linking redox state to cardiomyocyte proliferation and regenerative potential in mice.

Cortical parvalbumin neurons are responsible for homeostatic sleep rebound through CaMKII activation

This study identifies CaMKII-dependent activity of cortical parvalbumin neurons as essential for homeostatic sleep rebound following prolonged wakefulness.

ZIP13 regulates lipid metabolism by changing intracellular iron and zinc balance

This study shows ZIP13 regulates lipid metabolism by modulating intracellular iron and zinc balance in adipocytes.

Col4a2-eGFP mouse model reveals the molecular and functional dynamics of basement membrane remodelling in hair follicle morphogenesis

The study uses a fluorescent mouse model to show that basement membrane dynamics during hair follicle development are spatially graded and influence progenitor cell behavior and organ shape.

Truncated radial glia as a common precursor in the late corticogenesis of gyrencephalic mammals

The paper identifies truncated radial glia (tRG) as a conserved progenitor subtype in ferret and human corticogenesis, showing their role in brain expansion.

Targeting retrovirus-derived Rtl8a and 8b causes late onset obesity and neurodevelopmental defects

This study shows that Rtl8a and Rtl8b double knockout mice develop late-onset obesity and neurodevelopmental defects, indicating these retrovirus-derived genes are important for brain function.

TOB is an effector of the hippocampus-mediated acute stress response

This study investigates the role of TOB in hippocampal stress response, showing increased TOB levels after acute stress and altered neural circuits and behavior in Tob-KO mice.

Plasticity of Neural Connections Underlying Oxytocin-mediated Parental Behaviors of Male Mice

The paper identifies oxytocin neurons as key regulators of paternal caregiving in male mice and shows enhanced excitatory connections from lateral hypothalamus neurons in fathers.

Realization of phosphorylation hypothesis of sleep by mammalian CaMKIIβ

This study shows that CaMKIIβ phosphorylation regulates sleep duration and steps in mammals by modulating kinase activity in excitatory neurons.

Fluid flow-induced left-right asymmetric decay of Dand5 mRNA in the mouse embryo requires Bicc1-Ccr4 RNA degradation complex

The paper investigates how fluid flow induces asymmetric Dand5 mRNA decay in the mouse embryo through the Bicc1-Ccr4 RNA degradation complex.

Selective translation of epigenetic modifiers drives the developmental clock of neural stem cells

This study identifies Fbl's role in driving the developmental clock of neural stem cells through translational control of H3K27me3 modifiers.

Implantation-Competent Blastocyst-Like Structures from Mouse Pluripotent Stem Cells

This study generates implantation-competent blastocyst-like structures (iBCs) from mouse pluripotent stem cells, demonstrating their ability to implant and develop in vivo.

Hair Follicle Epidermal Stem Cells Define a Niche for Tactile Sensation

The paper identifies a niche of hair follicle epidermal stem cells that support tactile sensation by maintaining stable interfaces with mechanosensory structures.

Deletion of class II ARF causes essential tremors through Nav1.6 traffic impairment

This study shows that deletion of class II ARF causes essential tremors by impairing Nav1.6 trafficking to Purkinje cell axon initial segments.