Fumio Matsuzaki

Epigenetic-metabolic axis in the temporal scaling of mammalian cortical neurogenesis across species

The paper identifies H3K27me3-mediated repression and -ketoglutarate as key regulators of species-specific neurogenesis timescales across mammals.

In vivo transition in chromatin accessibility during differentiation of deep-layer excitatory neurons in the neocortex

The paper tracks chromatin accessibility changes in mouse embryonic deep-layer excitatory neurons during differentiation using RNA-seq and DNase-seq.

Restoration of retinal regenerative potential of Müller glia by disrupting intercellular Prox1 transfer

This study shows that disrupting Prox1 transfer to Müller glia in mice enables retinal regeneration and delays vision loss in a retinitis pigmentosa model.

Efficient workflow for validating homology-independent targeted integration-mediated gene insertion in rod photoreceptor cells to treat dominant-negative mutations causing retinitis pigmentosa

Truncated radial glia as a common precursor in the late corticogenesis of gyrencephalic mammals

The paper identifies truncated radial glia (tRG) as a conserved progenitor subtype in ferret and human corticogenesis, showing their role in brain expansion.

The cardiopharyngeal mesoderm contributes to lymphatic vessel development

This study identifies the cardiopharyngeal mesoderm as a non-venous source of lymphatic endothelial cells contributing to craniofacial and cardiac lymphatic networks.

Shear forces drive precise patterning of hair cells in the mammalian inner ear

This study shows that shear forces and local repulsion drive the formation of the checkerboard pattern of hair cells in the mammalian inner ear.

Selective translation of epigenetic modifiers drives the developmental clock of neural stem cells

This study identifies Fbl's role in driving the developmental clock of neural stem cells through translational control of H3K27me3 modifiers.