Enabling Epitope Analysis of Glycoproteins via HDX-MS Using Antigens with Uni-formed N-linked Glycans
Takeshi Ota, Masahiro Takayama, Takeshi Ishihara, Masaaki Sato, Sawaka Ono, Ryota Futamata, Masaya Fujitani, Masatomo Rokushima
This study shows that using antigens with uniform N-linked glycans improves epitope analysis of glycoproteins via HDX-MS, identifying epitopes including previously reported glycan sites for a monoclonal antibody.
bioRxiv · Sep 24, 2024 · PreprintBiochemistry