Development of MAPT S305 mutation models exhibiting elevated 4R tau expression, resulting in altered neuronal and astrocytic function
Kathryn R. Bowles, DA Pugh, Chiara Pedicone, Laura‐Maria Oja, S A Weitzman, Yale Liu, Ji‐Long Chen, Matthew David Disney, Alison Goate
This study develops isogenic iPSC lines with MAPT S305 mutations to increase 4R tau expression, revealing altered neuronal and astrocytic functions in tauopathies.
bioRxiv · Jun 2, 2023 · PreprintNeuroscience