Chiara Pedicone

Tau is an m6A-associated RNA binding protein that causes RNA dysregulation in disease

The paper identifies tau as an m6A-associated RNA binding protein that causes RNA dysregulation in MAPT coding-variant patients and V337M iNeurons.

Distribution of big tau isoforms in the human central and peripheral nervous system

The paper characterizes big tau isoforms in human nervous system tissues and CSF, finding they are enriched in the peripheral nervous system and largely unaffected by neurodegenerative disease.

Alternative Anastrozole Target CYP4V2 Impairs Neurons in Preclinical Models of Inherited Tauopathy

This study identifies anastrozole's off-target CYP4V2 as a neuroprotective factor in tauopathy models by reducing Tau phosphorylation and oxidative stress.

Integrated Manufacturing Platform for Cortical Organoids Reveals Early Phosphatase and Prefoldin Dysregulation in MAPT V337M Neurons

The paper develops a scalable cortical organoid platform with quality control metrics and identifies early dysregulation of phosphatase and prefoldin genes in FTD-tau neurons.

Development of MAPT S305 mutation models exhibiting elevated 4R tau expression, resulting in altered neuronal and astrocytic function

This study develops isogenic iPSC lines with MAPT S305 mutations to increase 4R tau expression, revealing altered neuronal and astrocytic functions in tauopathies.