Biochemical Characterization of a Fungal Bifunctional Type I Diterpene Synthase Brings a Cryptic Natural Product to Light
P. Zhang, G. Wu, S. C. Heard, C. Niu, S. A. Bell, F. Li, Y. Ye, Y. Zhang, J. M. Winter
The paper identifies a tnd biosynthetic cluster in Aspergillus flavipes and characterizes a bifunctional diterpene synthase, leading to the discovery of talarodiene and its transformation into talaronoid C.
bioRxiv · May 3, 2022 · PreprintBioengineering