Author

C. Niu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 2 Animal Behavior & Cognition· 1 Biochemistry· 1 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 5 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Assay:metabolomics· 2 Organism:mouse· 2 Assay:behavioral assay· 1

Frequent Co-Authors

Y. Wang· 3 shared B. Liu· 2 shared C. Yang· 2 shared J. Liu· 2 shared M. Lu· 2 shared A. A. Andongma· 1 shared A. Mansour· 1 shared A. Mazarin· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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3 shared papersImmunology

Y. Wang

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

SARS-CoV-2 spike protein induces the cytokine release syndrome by stimulating T cells to produce more IL-2

C. Niu, T. Liang, Y. Chen, S. Zhu, L. Zhou, N. Chen, L. Qian, Y. Wang, M. Li, X. Zhou, J. Cui

This study identifies that SARS-CoV-2 spike protein induces cytokine release syndrome by enhancing T cell production of IL-2, which drives inflammatory cytokine release through TLR4 and NF-κB activation.

bioRxiv · Nov 1, 2023Immunology

Inhibition mechanism and antiviral activity of an α-ketoamide based SARS-CoV-2 main protease inhibitor

X. Chen, X. Huang, Q. Ma, P. Kuzmic, B. Zhou, J. Xu, B. Liu, H. Jiang, W. Zhang, C. Yang, S. Wu, J. Huang, H. Li, C. Long, X. Zhao, , N. Zhong

This study identifies RAY1216, a slow-tight SARS-CoV-2 Mpro inhibitor with improved pharmacokinetics and antiviral activity compared to PF-07321332, currently in phase III clinical trials.

bioRxiv · Mar 9, 2023Biochemistry

Biochemical Characterization of a Fungal Bifunctional Type I Diterpene Synthase Brings a Cryptic Natural Product to Light

P. Zhang, G. Wu, S. C. Heard, C. Niu, S. A. Bell, F. Li, Y. Ye, Y. Zhang, J. M. Winter

The paper identifies a tnd biosynthetic cluster in Aspergillus flavipes and characterizes a bifunctional diterpene synthase, leading to the discovery of talarodiene and its transformation into talaronoid C.

bioRxiv · May 3, 2022 · PreprintBioengineering

TET1 controls Cxcl1 induction by DNA demethylation and promotes neutrophil recruitment during acute lung injury

K. M. Yee, R. W. Shuai, B. Liu, C. A. Huynh, C. Niu, H. R. Lee, M. S. Lee, J. Wen, J. Zou, J. Wu, K. Shuai

This study shows TET1 facilitates DNA demethylation of the Cxcl1 promoter, enabling its induction and neutrophil recruitment during acute lung injury.

bioRxiv · Sep 7, 2021 · PreprintImmunology

Dynamics of glioma-associated microglia and macrophages reveals their divergent roles in the immune response of brain

J. Qian, C. Wang, B. Wang, C. Li, K. Fu, Y. Wang, Y. Gao, C. Niu, C. Zhao, J. Liu, L. Wang, R. Liu, F. Luo, M. Lu, Y. Liu, Y. Chu

The paper uses single-cell sequencing to analyze glioma-associated microglia and macrophages, revealing their distinct roles in tumor progression and clinical outcomes.

bioRxiv · Jul 11, 2021 · PreprintImmunology

Host fruit as a suitable bacteria growth substrate that promotes larval development of Bactrocera dorsalis (Diptera: Tephritidae)

M. Akami, X. Ren, Y. Wang, A. Mansour, S. Cao, X. Qi, A. Ngakou, C. Niu

This study shows that banana supports better larval development and bacterial growth in Bactrocera dorsalis compared to apple, suggesting a link between host fruit quality and gut microbiota.

bioRxiv · Nov 7, 2019 · PreprintMicrobiology

Temporal modulation of host aerobic glycolysis determines the outcome of M. marinum infection

L. Meng, L. Xie, Y. Kan, L. Liu, W. Dong, J. Feng, Y. Yan, G. Peng, M. Lu, C. Yang, C. Niu

This study shows that pre-infection modulation of host glycolysis with 2-DG enhances resistance to M. marinum infection by reducing phagocytosis and bacterial proliferation.

bioRxiv · Dec 27, 2018Microbiology

Intestinal bacteria modulate the foraging behavior of the Oriental fruit fly Bactrocera dorsalis (Diptera: Tephritidae)

A. Mazarin, A. A. Andongma, C. Zhengzhong, J. Nan, K. Khaeso, E. Jurkevitch, C. Niu, B. Yuval

This study shows that gut bacteria in Oriental fruit flies influence foraging behavior by affecting how flies balance feeding time and nutrient intake.

bioRxiv · May 1, 2018Animal Behavior & Cognition