Nuclear Argonaute HRDE-1 Maintains Chromatin-Independent Transcriptional Silencing through a Transgenerational Small RNA Feedback Loop
Arantxa M. L. Rojas, Almira A. Chervova, Loan Bourdon, Jagannath Jayaraj, Ana Karina Morao, Olivier Ulrich Feudjio, Sofija Illic, S. A. Capurso, Piergiuseppe Quarato, Julie Ovieve, Germano Cecere
The paper shows HRDE-1 maintains transcriptional silencing in C. elegans without chromatin marks by promoting small RNA feedback loops.
bioRxiv · Sep 24, 2025 · PreprintMolecular Biology