Ana Karina Morao

The paper shows HRDE-1 maintains transcriptional silencing in C. elegans without chromatin marks by promoting small RNA feedback loops.

This study shows DNA supercoiling affects transcription initiation and elongation in C. elegans, with directional impacts on gene expression based on genomic context.

This study shows that topoisomerases I and II regulate condensin DC translocation on the X chromosome in C. elegans, with TOP-2 affecting long-range movement and TOP-1 affecting short-range movement, both essential for gene repression.

The paper shows that condensin DC spreads from rex sites to form TADs on the X-chromosome in C. elegans, but not on autosomes unless rex sites are artificially added.

The paper shows that increased gene dosage in C. elegans leads to increased mRNA expression, indicating no genome-wide dosage compensation mechanism at the mRNA level.

The paper introduces an engineered auxin analog and AtTIR1(F79G) pair to improve the specificity and efficacy of the auxin degradation system in C. elegans.

The paper shows that DCC binding reduces active histone modifications at X chromosome gene regulatory elements, fine-tuning X transcription.