IL-17A both initiates (via IFNγ suppression) and limits the pulmonary type 2 immune response to nematode infection
J. Ajendra, A. L. Chenery, J. E. Parkinson, B. H. Chan, S. Pearson, S. A. Colombo, L. Boon, R. K. Grencis, T. E. Sutherland, J. E. Allen
This study shows IL-17A suppresses IFNγ to initiate and later limits type-2 immune responses in the lung during nematode infection.
bioRxiv · Apr 18, 2020Immunology